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Potential risks to minimally symptomatic participants, some of whom might not progress to manifest Parkinson's disease, and individuals who do not wish to know their mutation carrier status, could pose specific ethical dilemmas in the design of these trials.
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The results indicate that the vibration isolators with an anti-symmetric damping characteristic have great potential to overcome the dilemma in the design of linear viscously damped vibration isolators where an increase of the damping level reduces the force transmissibility over resonant region but increases the transmissibility over non-resonant regions.
In the review, we have described the dilemmas inherent in the design of a viable, non-viral gene vector equipped with multiple functionalities.
In a word, the design of the MPER-based vaccine is replete with complications that require further elucidation; therefore, we still have a long way to go before the bNAbs dilemma, as detailed in this review, is settled.
As a result, the design of subarray partitioning is a complex dilemma both in theory and practice.
Our findings yield implications for the design of mechanisms intended to foster cooperation in social dilemma environments.
However, there is no clear guidance for the design of monolimb considering the dilemma between shank flexibility and structural integrity.
This paper examines the assumptions that underlie the design of appraisal schemes and identifies the difficulties and dilemmas inherent in the process.
The most topical dilemmas in the radiological assessment of renal and adrenal tumours are presented.
The authors present a Robust Geotechnical Design (RGD) approach for purposes of addressing this dilemma, by considering the robustness explicitly in the design process.
Additionally, the dilemma in the determination of the chemical compositions is also worsened by ionic absorptions.
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