Sentence examples for digit elongation from inspiring English sources
This digit elongation is extreme.
Overall, our examination of differentially expressed genes revealed candidate genes associated with both digit elongation as well as morphological and functional similarities between the thumb and hindlimb digits.
Among hundreds of genes exhibiting significant differences in expression between the short and long digits, we highlight 14 genes most related to digit elongation.
Among the differentially expressed genes, we found 14 genes likely related to digit elongation based on results of previous studies (see Discussion).
Here, we capitalized on the morphological variation among the bat forelimb digits to investigate the molecular mechanisms underlying digit elongation and wing formation.
Results of this study not only implicate many developmental genes as robust candidates underlying digit elongation and wing formation in bats, but also provide a better understanding of the genes involved in autopodial development in general.
Their analyses revealed a consistent association of decreases in limb length, digit loss, and body elongation across ecologically and phylogenetically diverse squamate clades, indicating an influence of shared functional and developmental constraints on the evolution of body form.
Just such an upregulation of Bmp2 might have powered the elongation of the three digits in an ancestor to the bat 50 million or more years ago, helping to make winged flight possible.
This rapid elongation of the posterior forelimb digits is thought to results from modification in expression of key developmental genes [ 5, 6].
Using these data, we compared gene expression profiles among the libraries to identify candidate genes associated with elongation of the posterior forelimb digits (Hand DII-V).
First, a mouse transgenic experiment that replaced an enhancer of the mouse Prx1 - a transcription factor that regulates long bone growth in mouse - with the orthologous putative enhancer sequence from a bat resulted first in an increase in Prx1 expression and second in a small, but significant elongation of the mouse forelimb digits [ 7, 8].
