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The patient was found on admission to have hyperglycemia and a diffuse skin rash.
Less common presentations include nipple retraction or discharge and diffuse skin thickening and oedema, mimicking inflammatory breast cancer [8].
Tubercular mastitis, like idiopathic granulomatous mastitis, is also an inflammatory pathology occurring in young parous women and presents with increased breast density with diffuse skin thickening; however, their management differs completely.
a Axial contrast-enhanced T1-weighted MR image before start of neoadjuvant chemotherapy shows diffuse skin thickening and edema involving the right breast, with multiple enhancing masses (arrowheads) and enlarged right axillary lymph nodes (arrow).
All five had diffuse skin involvement as defined by LeRoy et al [43], and disease duration of less than five years.
A diffuse skin rash is noticed, characterised by numerous small purple punctate lesions.
Similar(28)
In the current study, we examine CD109 expression and function in limited SSc and diffuse SSc skin and normal skin in vivo, and in SSc and normal dermal fibroblasts and epidermal keratinocytes in vitro.
Our data showing that the levels of CD109 protein, but not of mRNA, are higher in limited SSc and diffuse SSc skin fibroblasts compared with normal skin fibroblasts suggests that post-transcriptional regulation of CD109 may be altered in limited SSc and diffuse SSc skin.
Taken together, this study identifies CD109 as a novel protein overexpressed in limited SSc and diffuse SSc skin fibroblasts and indicates that CD109 inhibits Smad2/3 signaling and ECM/CCN2 production in these cells, as in normal skin fibroblasts.
Friction discolouration (FD) is a serious postharvest disorder in pear generally categorised by diffuse brown skin marks that occur as a result of mechanical damage and lead to the enzymatic browning of the fruit skin.
Unfortunately, NTXOL does not diffuse across skin at a therapeutic rate.
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