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'Treatable lesions' included discrete points of retinal hyperfluorescence or leakage (most of these are often microaneurysms), areas of diffuse leakage within the retina related to microaneurysms, intraretinal microvascular abnormalities, diffusely leaking retinal capillary bed and retinal avascular zones.
Remaining leakage was classified as diffuse leakage.
This suggests that diffuse leakage may be a marker of VEGF-mediated pathobiology.
The difference in treatment response between focal and diffuse leakage was statistically significant (P = 0.01).Anti-VEGF treatment for DME results in decreased diffuse leakage but had relatively little effect on focal leakage as assessed by FA.
Diffuse leakage of fluorescein was observed from the posterior and peripheral retina as well as the optic disc (Figure 5).
On the FA image diffuse parafoveolar oedema was present as well as diffuse leakage along the major retinal vessels.
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In patients with diffuse venous leakage structural changes in the corpora cavernosa have correlated with failure of the veno-occlusive mechanism.
On fluorescein angiography, the diffuse retinal leakage had improved at 5 weeks and had resolved after 4 months on a slow topical corticosteroid taper (Fig. 2c f).
Macular edema in humans is a result of diffuse capillary leakage and microaneurysms in the macular region.
Macular edema was defined by central thickening revealed with biomicroscopy using a 78-diopter non-contact lens and by diffuse fluorescein leakage on fluorescein angiography (FA).
The endothelium is a key target of sepsis-induced events, and the sepsis-activated vascular endothelium is responsible for the increase in luminal cell adhesion molecules, leukocyte recruitment, vasomotor tone alteration, microvascular thrombosis formation, and eventually diffuse capillary leakage [ 4, 5].
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