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We suggest, that DCI can lead to diffuse encephalopathy, that affect the level of consciousness, that is why we revealed significant difference in ADR, TDR between groups of pts. with different level of consciousness.
Following an initial stage of diffuse encephalopathy, the neurological sequelae are usually characterised by diffuse cognitive deficits and extrapyramidal or cortico-bulbo-spinal signs; however, a complete remission of neurological symptoms can also be achieved.
CM is characterized by a range of acute neurological manifestations including a diffuse encephalopathy, alteration in levels of consciousness, deep coma and seizure preceding death [6], [7].
Clinically, it is defined as a diffuse encephalopathy causing unrousable coma often associated with seizures in the presence of asexual forms of P. falciparum in peripheral blood and not attributable to other causes of unconsciousness [3].
Electroencephalogram demonstrated diffuse encephalopathy.
Electroencephalogram demonstrated severe diffuse encephalopathy.
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On examination, neurologic abnormalities resemble those of a diffuse symmetric encephalopathy, similar to a metabolic encephalopathy.
3– 5 Cerebral malaria is the most lethal complication of falciparum infection, presenting as a diffuse symmetric encephalopathy with alterations in the level of consciousness, ranging from drowsiness to deep coma, at times precipitated by seizures.
Acute and intense COP can lead directly to diffuse hypoxic-ischemic encephalopathy and predominantly involve the gray matter [ 14].
Before TH became a widely used treatment of hypoxic/ischemic encephalopathy, diffuse EEG background suppression below 20 μV, burst-suppression with generalized epileptiform activity, or generalized periodic complexes on a flat background have been associated with poor outcome [ 16, 17].
Magnetic resonance imaging (MRI) is more sensitive than computed tomography at detecting stroke in the early phase, subtle abnormalities related to anoxic/hypoxic encephalopathy, and diffuse axonal injury (DAI) in patients with TBI.
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