On August 19, a Hurricane Hunters flight into the storm failed to locate a well-defined center and on the following day, a flight found that the cyclone had degenerated to the extent that only a diffuse low-level circulation center remained; observations indicated the pressure rose to an unusually high 1015 mbar.
Once synthesized, ketones diffuse into the circulation.
For NLC/PI-Dac, although the drug in the outer layer of the NLCs could diffuse into the blood circulation, the drug incorporated inside NLC could be carried over to the side of action, therefore improving the Dac therapeutic profile.
Another possibility is that the somatic spontaneous Ca2+ surges are evoked by ligands that are secreted by a more diffuse secretory system like circulation and astrocytes that express sufficient amount of corresponding receptors.
During intestinal ischemia permeability increases due to decreased mucosal integrity and D-lactate may diffuse into the portal circulation [ 6, 7].
In brief, volatile molecules of essential oil may diffuse into the systemic circulation through the lung, which inhalation takes them to.
The pattern of VS in PM-NASAH is typically confined to the posterior circulation, although diffuse VS has been described [ 9].
As the placenta's diffusing capacity increases with gestational age [ 38], perhaps fetal health was more greatly compromised later in pregnancy with higher CO doses, as more potent CO was able to diffuse to the fetal circulation.
The protein fragments contain pathology-specific neoepitopes that may serve as specific cancer biomarker targets that most likely enter the circulation by diffusing into the leaky vasculature found in tumor tissue.
These trials have shown evidence of tumour response (Bagshawe et al, 1995; Napier et al, 2000), however, toxicity was thought to have resulted from the long half-life of the activated drug, which diffused back into the circulation to cause myelosuppression (Springer et al, 1993; Martin et al, 1997).
