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Patients with sensory hypersensitivity have difficulty tuning out otherwise neutral stimuli such as the tag in their shirt or the voices of people around them.
Passive energy dissipation has advantages such as low cost, easily predictable response, and ease of implementation, which can be offset by difficulty tuning or designing the devices for optimum behaviour over a range of inputs and responses.
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The difficulty is tuning an IDS correctly, so that it spots mischievous behaviour reliably without sounding too many false alarms.
However the difficulty for tuning procedures increase as multiple requirements and criteria to evaluate the closed loop performance are demanded to be fulfilled.
Unfortunately, this increased speed currently comes at the cost of significantly increased difficulty in tuning protein function.
While the AuNP based fluorescent assays are very sensitive, the difficulty in tuning the binding affinity to match the experimental conditions has limited their broader applicability.
As for the languages I'm studying for my degree, although there have been some difficulties with tuning into the local dialects of German and Italian, I'm convinced that encountering two foreign languages every day has helped my confidence.
Yet it also has a number of drawbacks, including the deficiency for physical interpretations of results, and difficulties in tuning the training and iteration parameters.
At present, no M2 blocker is active against both wild type and all circulating M2-mutant strains, likely due to difficulties in tuning the structure of small molecule-based inhibitors to fit each of the individual mutant M2 ion channel proteins.
These are coded into an action gaming environment with patents pending both for the way in which the streams of information are displayed to the user and the Akili-developed adaptive algorithms to make the difficulty constantly tuned to the user so the entire experience is automatically personalized.
Despite tuning difficulties caused by a broken string, the Rose Consort of Viols presented an engaging programme based on the Elizabethan vogue for child actors.
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