There were construction difficulties to surmount.
Why make the difficulty in order to surmount it?
In Paley's words, Why make the difficulty in order to surmount it?
And here arises the further difficulty to be surmounted by correct non-winning thought: the non-winner is inclined to feel guilty at letting the publishers down.
You must learn to surmount difficulties no matterhow large.
From Lincoln's obsession with books and newspapers to Elvis Presley's fascination with movies and soundtracks, Wolff ties these and other personalities (W.E.B. DuBois, George Washington, Abigail Adams, Helen Keller, JFK, and more) together with common historical threads, discerning how each was able to surmount difficulties and make his or her mark.
The inverse problem is certainly not exclusive of systems biology: it has been extensively studied in other areas, as reviewed in [ 39], each one contributing with somewhat different perspectives regarding the difficulties encountered and how to surmount them.
It also seems that any process that requires the mind "to exert its activity, and put forth its strength, in order to surmount any difficulty," is naturally pleasurable, as is the mind's consciousness of its success in surmounting any difficulty (Gerard 1759, 3).
To surmount this difficulty, an optimization procedure consisting of constrained minimization of the total protein consumption by the CS was designed.
An algorithm FDBS (fast direct Biot Savart integration) is proposed to surmount this difficulty, which improves the traditional method (DBS, direct implementing Biot Savart law for all strand sources) in terms of computational effort.
In order to surmount this difficulty, the toolbox integrates several metaheuristics (Egea et al., 2007), clustering methods (Csendes et al., 2008) and sequential hybrids (Balsa-Canto et al., 2005, 2008b), which combine different mechanisms of global exploration of the search space with the use of local methods to enhance computational efficiency.
