Sentence examples for difficulty to scale from inspiring English sources

The major drawback for the progression of polymeric particles towards clinics is the difficulty to scale up and to develop cost-effective individual manufacturing processes under aseptic good manufacturing practices (GMPs).

These studies focus on new technologies, processes, and approaches for improving humanitarian aid; they address funding, budgeting, and institutional support and explore the challenges of developing good use cases and evidence-based practices and the difficulty of bringing innovations to scale.

Financial difficulties have forced Mr. Gingrich to scale back his activities, essentially ending any formal campaigning for the nomination.

The median returns to scale and elasticity of substitution between money and time is in the 1.2 1.9 range and.33 .56 range, respectively, indicating increasing returns to scale but difficulty in substituting money for time in home meal production.

Besides the general difficulties related to scale formation, like blockage of pipes, related decrease of well productivity, and disturbances in geothermal plant operation, (Ba,Sr SO4 solid-solutions tend to incorporate natural radium isotopes (mainly 226Ra and 228Ra) to an extent that they may even become a radiological concern (Degering et al. 2011; IAEA 2003).

This puts them at the top of the pack for potential entrepreneur leaders, even if those entrepreneurs face difficulties when it comes to scaling their businesses.

Relief and assessment activities have had dramatic difficulty to determine the scale of the disaster and the death toll is expected to swell.

Due to these reasons, arc-discharge and laser ablation synthesis methods are not a challenging technique due to difficulty in scaling up to commercial production.

On the other side is greater challenge than ever before due to the difficulty related to scales and scaling.

The SDI-21 [ 27] assesses various everyday difficulties commonly experienced by cancer patients, including relationship difficulties, domestic problems and financial worries; 21 questions (e.g. "have you felt isolated", "have you had any financial difficulties") are answered on a 0 (no difficulty) to 3 (very much) scale with respect to the past month.

Existing integration technologies are able to support the safe and stable operation of small-scale RES, but have difficulty to assure that of large-scale RES due to drawbacks such as small storage capacity, imperfect communication and control devices, and low levels of automatic energy management [7, 8].