The cost results from the difficulty of having to optimize many phenotypes simultaneously and it is manifested by the decreasing fraction of beneficial mutations as dimensionality increases [ 11, 13, 15, 21].
Ways to improve shared decision making among practitioners, parents and youth, and to monitor effectiveness, safety and new onset of concurrent difficulties are likely to optimize outcomes.
In addition, because of its psychoactive side effects, difficulty in dose titration to optimize benefit, minimize side effects like dizziness, dysphoria, depression, hallucinations, alteration in psychomotor function and paranoia, time to response and long-term effects when taken orally limits the use of this agent for all cancer patients with symptoms of cancer anorexia [ 41].
Patients with Parkinson's disease (PD) have difficulties in movement adaptation to optimize performance in novel environmental contexts such as altered screen cursor-hand relationships.
The difficulty in this project is how to optimize the inlet and outlet structures to minimize its effect on engine performance and reduce the emissions of harmful gases.
A systematic way to handle the difficulty in determining appropriate event costs is to optimize for event counts rather than total numerical cost.
Considering the difficulty of determining the structural parameters of neural network, EAs are used to optimize the neural network parameters for fault classification and prediction.
Respondents expressed their interest in individual work; it allows them to optimize time because of the technical and timing difficulties involved in synchronous meetings.
However, the difficulty of the large scale fabrication hinders their practical applications, and the structure tuning of the nanomaterials to optimize PSC is still challenging.
