Sentence examples for difficulty to isolate from inspiring English sources
The functional heterogeneity among cancer stem cells and bulk cells must reflect distinct cellular epigenetic landscapes, but — due to the difficulty to isolate bona fide cancer stem cells with a high degree of purity — those different epigenetic landscapes, and the molecular mechanisms underlying them, remain largely unknown.
However, technical difficulty to isolate and characterize these progenitor types due to the complex lung structure continues to hinder the understanding of the role of endogenous regenerative pathways in lung tissue maintenance and repair in response to injuries.
We have not been able to measure intracellular NAD levels in inflammatory cells isolated from the paws of CIA mice due to the paucity of the cells and the difficulty to isolate them with high purity.
Studies on the feasibility of immunotherapeutic strategies in bone tumors are often hampered by the technical difficulty to isolate viable fresh tumor cells for functional testing.
Results remained questionable given the coarse resolution of the source material, the difficulty to isolate climatic influences from human influences and the variable link between greenness trends and soil (land) degradation.
Because of the difficulty to isolate and obtain an uncontaminated population of latently infected cells, only a limited number of studies investigated the cellular transcriptome of HIV latency in primary models.
Mr. Patten said the Union would move swiftly to bolster the relief assistance it has already provided in small quantities, and with difficulty, to isolated Serbian cities governed by the opposition to Mr. Milosevic.
Although epidemiological studies show difficulties to isolate the links between the different parameters involved, some results could guide us to relate the effects of Electromagnetic Fields with these kind of diseases.
Despite these interesting early studies and the growing economic burden of PRDC in the porcine industry, PIM have rarely been considered in pig respiratory diseases during the last 10 years, most probably due to the difficulties to isolate and characterize them phenotypically and functionally.
Facing the safety concerns of ESCs, and the difficulties to isolate and exploit adult stem cells for dental therapies in clinics, induced pluripotent stem cells (iPSCs) which could be another option to regenerate lost tooth or to repair a tooth injury.
Because of these similarities and to overcome the difficulties to isolate primary pericytes, as reported by several authors [ 16, 17], in our work we used MSCs as pericytes.
