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Indeed, a very recently published study by Gemer et al (2009) has underscored the difficulty to devise generally applicable models able to reliably predict surgical outcome in advanced ovarian cancer patients, across different Institutions.
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While these results lend further support to the use of medications-related data elements for biosurveillance [29], [30], [31], the practical difficulty is to devise database queries that, over time, will continue to reflect the concept of "cough remedies".
"It would probably be impossible to devise a scheme which is completely free from difficulty," he said.
The difficulty in choosing a model for heritability H makes it hard to devise an unambiguous definition for H. Thus, any estimate of predictive accuracy should be taken only as a rough indication of precision.
Young children often have difficulty swallowing pills, tablets and capsules, so companies could have been required to devise liquid, chewable or injectable forms.
Economists have tried to devise abstract voting schemes that would reconcile these difficulties, but these appear to have little practical application.
Early attempts to devise a blast-furnace process for zinc production failed because of the difficulty of condensing zinc vapour from a gas containing substantial quantities of carbon dioxide.
Mr. Goldstein said it was entirely possible to devise advertising strategies that correlate this closely without speaking directly by monitoring purchases, highlighting the difficulty such cases will have before regulators or judges.
This difficulty factor also ruled out Latin and classical Greek - all of which left Zamenhof with only one option: to devise his own language.
Director David Silverman had difficulty devising a legible Scrabble board for the opening scene that would convey the idea that the Simpsons were only able to devise very simple words.
The difficulties inherent in blocking a pleiotropic blocker pose a great obstacle for the classical receptor antagonist approach and have contributed to the failure (to date) to devise specific treatments for cocaine overdose and addiction.
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