Sentence examples for difficulty to define a from inspiring English sources

Given the high number of missed appointments and the difficulty to define a specific profile of non-attenders, large scale implementation of such interventions does not appear to be realistic, at least in our context.

A limitation of FBA, MOMA and FVA is the difficulty to define a relevant objective function: for example, the objective function to predict cell growth typically involves a linear combination of more than 100 metabolites (Raman and Chandra, 2009).

The difficulty to define a progression scheme with increasing numbers of CNAs according to disease stages may be related to the fact that CRC staging is a clinical progression scale which takes local and distal invasion into account and no tumor intrinsic characteristics.

Theoretically, the problem persists mainly due to the difficulty to define an appropriate parameter for determining the diameter.

One reason could be the difficulty to define an objective and quantitative measure of organismal complexity.

This issue is partly semantic, but it shows the limitations of Murray and Frenk's framework and, by extension, the difficulties to define a health system.

This mix of clones with different susceptibility causes a trailing endpoint in MIC distribution diagrams and difficulties to define a wild type cutoff value to separate the wild type from isolates with acquired decreased susceptibility.

Finally, it has to be underlined that the focus on CNVRs is accompanied by (a) the difficulty to define the CNV markers that make up a CNV and (b) the difficulty to assess when and if association signals in different samples pertain to the same source.

Still, no attempt to quantify the contamination level of the pens was performed in the present study, due to an expected uneven distribution of Salmonella in the contaminated pens with a subsequent difficulty to define the true pathogen load.

Although creativity is part of human cognitive function, there are difficulties to define creativity and to measure it.

When we designed the original three difficulty modes of BioShock, we tried to define a spectrum encompasses as much of the shooter audience as we could, balanced as optimally as possible.