They have three major weaknesses, namely incompleteness (DeRemer 1998; Smith 2000), possible alteration in the rating due to simultaneous verbalization and rating (Barkaoui 2011; Lumley 2005) and the difficulty to administer TAPs (Barkaoui 2011; Siddiqui 2016).
Current drug treatments of visceral leishmaniasis suffer from various drawbacks such as host toxicity, high cost, difficulty to administer and drug-resistance development.
In October and November tens of thousands of volunteers overcame many difficulties to administer drops of OPV into the mouths of nearly 80 million children in 23 African countries.
However, currently available treatments suffer numerous drawbacks including poor efficacy, difficulties to administer, insecure supplies, cost, and an increasing threat of resistance.
Many diabetics, he notes, have difficulty learning to administer proper wound care, and many other patients do not follow doctors' orders or show up for scheduled visits.
Given the complex nature of the disease and difficulty related to administering the treatments and scoring the data, the level of repeatability observed was high for all traits, indicating that biologically meaningful QTL are responsible for much of the phenotypic variation reflected in the population.
An additional difficulty in the decision to administer adjuvant treatment may be the new tumour-node-metastasis (TNM) classification [13,14].
Indeed, the rise and strength of Jabhat al-Nusra relies heavily on the current difficulties of the insurgency to administer the distribution of food and basic supplies.
Stacy Albin (NYT) ITHACA: DEER POPULATION CONTROL Contraceptive injections could help curb an exploding deer population in areas of upstate New York, researchers say, although the contraceptives' effectiveness is limited by the difficulty of catching the deer to administer the medication.
Due to the comprehensive materials we sought to administer, we anticipated difficulty in recruiting participants, and so began by approaching contacts in the teaching faculty of high schools region-wide during the first few weeks of the school year.
If subjects had difficulty completing the questionnaire, the research assistant helped to administer the questionnaire.
