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How we deal with this difficulty requires sensitivity to competing interests, now and in the future, and a full appreciation of legal, social, technical, economic, and ethical considerations.
To overcome this difficulty requires the use of special simulation techniques (Li and Scheraga 1987; Rahman and Tully 2002; Minary et al. 2004; Curuksu and Zacharias 2009) to achieve effective sampling of conformational space.
Toward the end of the introduction to his analysis of place, Aristotle notes that "Zeno's difficulty requires some explanation; for if every thing that is is in a place, it is clear that there will also be a place of the place, and so on to infinity" (Arist. Ph. 4.1.209a23 5).
Understanding this difficulty requires an appreciation of how Notch is activated: binding of DLL1 or Jag1 ligands to the Notch extra-cellular domain triggers a conformational change that exposes a β-strand of Notch to cleavage by ADAM family metalloproteases [41], [42].
The assessment of voiding difficulty requires the control of several confounders: hydration status, administration of agents during GA [ 9].
Twin, recurrence risk, and prospective tracking studies have not only improved our understanding of the etiology of neurodevelopmental conditions but also bolstered our capacity to identify children at risk of particular conditions in order to effectively intervene before the emergence of stable and severe levels of difficulty requires costly remediation.
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It escapes its period with difficulty, requiring the kind of treatment it received on Wednesday.
But it has long faced financial difficulty, requiring several cash infusions from outside investors.
Previously healthy children developed severe brain inflammation or breathing difficulty, requiring support from mechanical respirators and treatment in intensive care.
Possible explanations for a high incidence of AKI in OPCAB include hemodynamically induced renal ischemia, atheroembolism from side clamping, and a technical difficulty requiring heart displacement.
McAvoy, who as also a former in-house counsel for Morgan Stanley, noted the difficulty required to bring in these kind of charges.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com