Sentence examples for difficulty primarily from inspiring English sources

However, despite these promising pre-clinical data, clinical application of the anti-CD154 antibodies has been wrought with difficulty primarily due to serious thromboembolic complications [ 17, 19].

However, such methodology can be fraught with difficulty, primarily related to the considerable uncertainty regarding the potential events after follow-up and, more specifically, around the handling of censored data and the correct approach to parameterisation of survival estimates.

I've experienced mental health difficulties – primarily depression – since my late teens.

Bush administration officials deny that the program is dead, but acknowledge that it has difficulties, primarily financial ones.

Bush administration officials deny that the program is dead, but acknowledge that the future of the program has difficulties, primarily financial ones.

On the improvement front, organizers of Advertising Week are hoping to untangle logistical difficulties, primarily complaints from attendees that the sites for events are spread across Manhattan.

But Walsh himself was suffering from physical difficulties, primarily fading sight in his one good eye, and he had to retire after this.

Nevertheless, the estimation of counterfactual differences pose several difficulties, primarily in observational studies.

Early symptoms of ADHD were linked to parent-reported difficulties primarily within inhibition and working memory, suggesting that deficiencies within these two EF domains characterize early forms of ADHD.

While quantifying the potential health impact of policy options is preferable over qualitative assessment, doing so is subject to several difficulties, primarily the availability of evidence 47 and the potential to add scientific credibility to uncertain predictions.

Adaptive management has been difficult to implement in certain instances, although a systematic review suggests that difficulties primarily stem from application of the framework in inappropriate contexts (Gregory et al. 2006).