Sentence examples for difficulty of validation from inspiring English sources

Our study highlights the importance and difficulty of validation of predictive genotype-base biomarkers in severe sepsis.

Tractography offers such an opportunity but suffers from the difficulty of validation due to the lack of within subject "ground truth".

However, one possible drawback of long inserts could arguably be an increased difficulty of validation, since PCR product sizes may be prohibitively large when few reads span a breakpoint.

A problem for law enforcement and clinical laboratories occurs due to the difficulties of validation and maintenance of multiple analytical methods used in the accurate and precise detection of these compounds.

The practical and ethical difficulties of validation by clinical trial may be insurmountable, and an alternative approach to validation is proposed which does not raise these difficulties.

The strength anisotropy under compression has been relatively well established, whereas the formulation of the tensile strength anisotropy has received less attention due to the difficulty of experimental validation.

Previous studies have shown the difficulties of external validation in datasets from different microarray platforms and the performances of the classifiers dropped dramatically [ 53, 54].This study is the first to assess whether lncRNAs can be used for prognostic profiling in breast cancer.

However, several limitations of these markers should be taken into account, including low specificity, qualitative assessment of microaspiration, short window for their detection in tracheal aspirates, technical difficulties, and absence of validation compared with the gold standard.

Potential limitations of immunodiagnostic methods include inability to detect some Legionella species, difficulty with validation of infection by unusual strains (due to lack of clinical material) and the potential for cross-reactivity.

The difficulty of a comprehensive analytical validation of a highly complex genomic multianalyte assay such as EndoPredict is that there are no evaluation guidelines to cover all relevant aspects.

Although these procedures have predicted many candidates with the potential to form qualified hairpins, only a limited number of hairpins have been confirmed experimentally on the basis of expression due to the difficulty of large-scale expression validation and low prediction accuracy for expressed miRNAs.