"I am often asked if the difficulty of running a company in a rural area is high-speed internet.
Music discovery site This Is My Jam is to close after four years, citing the difficulty of running the music-focused startup in an age of increasing online centralisation and ever-stricter copyright regimes for embedded audio.
He also points out that some of the oddities of his company, such as its schools and clinics, have been around for a century and derive from the difficulties of running a railway in the middle of nowhere.
One of the difficulties of running a conference in this era are what Jay Rosen calls the backchannels - a-la Twitter, Facebook, Email.
Representative Anthony D. Weiner, a Brooklyn Democrat who voted for the oil reserve, said yesterday that he understood the difficulty of running for the Senate while serving in Congress, and he noted that the House leaders had indicated that they intended to finish the day's business by 6 p.m.
The campaign's chief strategist, Mark Penn, and its communications director, Howard Wolfson, have expressed frustration with the difficulty of "running against a phenomenon" in Senator Barack Obama; their attacks have not stopped Mr. Obama from winning the last 11 contests.
The company ended up running up against the difficulty of making money in the cut-throat business of Bitcoin mining, which became much more difficult as the price of Bitcoin dropped over the last year.
And it's worth noting that this model is apparently a pivot from 21.co's original business model, after "the company ended up running up against the difficulty of making money in the cut-throat business of Bitcoin mining".
He spoke of the difficulty of running two wars at once — the war on poverty and the war in Vietnam.
One of the major reasons for the paucity of mammalian Pol II terminator sequences in the literature is that examination of termination mechanisms is hindered by the technical difficulty of mapping nascent transcripts in nuclear run on experiments (Proudfoot, 1989).
