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The limitation, as with all such tools, relates to the difficulty of standardizing across observers and sites the exact behaviors that must be observed to demonstrate competency in a certain area.
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This discrepancy may, however, be explained partly by the small size of our cohort, the exclusion of acute neurologic diseases in our study, the absence of a standardized protocol for sedation and antipsychotic medications, and the difficulties of standardizing the recording of the ICDSC items by both nurses and physicians.
This emphasizes the potential difficulties of standardizing this reagent.
A key problem in the validation of a new assay of amyloid growth is the difficulty of obtaining standardized and calibrated aggregation conditions because the observed growth kinetics are the result of a complex interplay of underlying elementary reaction steps.
"I have no sense of standardizing what goes on here.
Microsoft's MSN doesn't do much in this realm because of the difficulty in standardizing databases across all of its services.
Microsoft's MSN doesn't do much in this realm because of difficulties in standardizing databases across all of its services.
However, uncertainty persists given the limitations of existing studies and the difficulty in standardizing such regenerative therapy protocols [ 11].
The infrequency of surgical conditions, parents' refusal to participate, and difficulty with standardizing operative technique are potential obstacles to conducting multicenter randomized trials.
The difficulty in standardizing these natural substrates, together with arbitrary interpretation of the indirect immunofluorescence pattern, has hampered the widespread use of these tests.
These include difficulty in standardizing the vaccine because it is administered via scarification and phenotypic instability of the vaccine strain.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com