Snafus and slow-downs at major Web sites during special events or peak times demonstrate the difficulty of scaling up e-commerce sites.
Much of the difficulty of scaling up was attributed to the "knowledge acquisition bottleneck"—the difficulty of coding or acquiring the myriad facts and rules evidently required for more general understanding.
It is possible that the experimental difficulty of scaling up quantum simulation hardware might cause an overhead such that a quantum device does not surpass the accuracy obtained by a classical algorithm that in principle does not scale as well but runs on ever-improving hardware obeying Moore's law.
The original design of the decoupling combustion was based on coal pyrolysis incurring with the heat transferring from the char combustion zone, thus causing the difficulty of scale-up in matching the reactions of slow coal pyrolysis and quick char combustion.
The major drawback for the progression of polymeric particles towards clinics is the difficulty to scale up and to develop cost-effective individual manufacturing processes under aseptic good manufacturing practices (GMPs).
The demographic make-up of the KIs (i.e., their professional background and institutional affiliation) is likely to have influenced their views on the difficulties of scaling up global health interventions.
The small enrollment in some workshops highlights potential difficulties of scaling up in rural areas as these areas typically have smaller class sizes due to population dispersion and lack of infrastructure supports.
Substantial efforts have been made globally towards improving Cu(In,Ga Se2 thin film solar cell efficiencies with several organisations successfully exceeding the 20% barrier on a research level using the three-stage CIGS process, but commercial mass production of the three-stage process has been limited due to the technological difficulties of scaling-up.
Functional characterization of these genomes, such as by high-throughput proteomics, is an important but challenging task due to the difficulty of scaling up existing experimental techniques.
The difficulties we encountered with training and supervision underscore the challenges of scaling up even the most basic components of a quality improvement intervention.
Although some of these methods have convenient protocols with good to high yields, the majority of these methods suffer at least from one of the following disadvantages: reaction under oxidizing conditions, prolonged reaction time, high temperatures, use of moisture-sensitive and expensive catalysts, use of solvents, strong conditions, difficulty in scaling up, etc.
