Sentence examples for difficulty of replication from inspiring English sources
Even with the difficulty of replication notwithstanding, variants with relatively large effects may be identified and replicated in powerful GWA studies [11].
Hence the difficulty of replication.
It also lists methodological challenges researchers can encounter when conducting field experiments, including failure to treat, selective attrition, spillover, difficulty of replication, and black box causality, and discusses available solutions.
Another factor that may contribute to the difficulty of replication in this field is the possibility that the s allele actually increases sensitivity to the environment in a more general way so that adverse environments will lead to bad outcomes, while positive and supportive environments will lead to benefits.
Although the number of GWASs has grown dramatically during the last five years [ 36, 37], GWASs have several limitations, such as small sample size, dependence on minor allele frequency and genetic effects, stringent statistical significance, and the difficulty of replication across studies [ 38].
Despite the difficulties of replication under a complex model of disease, it is still important to have a strategy for analysis and interpretation of results.
Our analysis suggests that experimental design with various conditions overcomes the difficulty of lack of replications.
Also, the locus heterogeneity, which implies that alleles at different loci target the same diseases in different individuals, would increase difficulty in replication of association of a single marker [ 1].
The reasons may be found in a complex set of unrelated problems of which difficulties in replication of low-dose stimulatory responses resulting from poor study designs, greater societal interest in high-dose effects, linking of the concept of hormesis to the practice of homeopathy, and perhaps most crucially a complete lack of strong leadership to advocate its acceptance in the right circles.
The difficulty of including sufficient statistical replication in the design of large-scale honey bee field trials, such as this, is well described in the both the original Pilling et al.'s [3] paper and in the EPPO [2] Field testing Guideline followed.
