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Our structure selection results highlight the difficulty of reliable structure prediction by first-principles calculations.
(iii) Underestimation of the volume in situ, hence the difficulty of reliable clinical utilization.
Its full distribution pattern, however, remains uncertain owing to the difficulty of reliable species identification.
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However, we quickly abandoned RF because of the issues of cost, multipath, fading, interference from other sources, and the difficulty of making reliable directional antennas.
However, due to the difficulty of gathering reliable epidemiological data describing how infection is transmitted from one setting to another, these techniques have not been used to estimate the relative importance of different social contexts in the spread of influenza.
Reports from Crimea feature some people very supportive of recent Russian actions and some extremely critical, but the balance is impossible to know given the enormous difficulty of conducting reliable polls in the current context.
The contradictory statements and sudden round of finger-pointing seemed to underscore once again the difficulty of obtaining reliable information — and making educated guesses — about one of the world's most closed societies.
But another important reason may be the difficulty of developing reliable metrics to measure the performances of employees who work at home, especially when they are involved in team projects.
More broadly, the phantom attacks underscore the longstanding difficulty of gaining reliable information about America's drone program in the remote and largely inaccessible tribal belt — particularly at a time when the program is under sharp scrutiny in Washington.
Or the united front it now faces may crumble, given both the difficulty of crafting reliable verification rules for such a mendacious regime and the likely need to twist North Korea's arm further to accept them.
Recent debate about the evaluation of community based, HIV/AIDS behavioural interventions has focused on the appropriateness of the randomised controlled trial (RCT) design, and the difficulty of obtaining reliable outcome measures.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com