Sentence examples for difficulty of manipulating from inspiring English sources

Biopsy of palpable breast tumors and especially of nonpalpable breast lesions, which are performed with needle guidance, can be technically tedious because of the difficulty of manipulating the tumor in the former and the needle in the latter.

Given the inherent difficulty of manipulating embryonic stem cells, we have achieved relatively high delivery efficiency in a short time (2 3 hours) with a single infection.

Despite such encouraging advances, the application of hESC-derived cardiomyocytes for basic developmental research and large-scale applications, such as high throughput screening, toxicology testing and large animal studies, has been hindered by their poor yield from the heterogeneous hESC cultures and the difficulty of manipulating hESCs to express uniform levels of reporter constructs.

However, this research is generally conducted in controlled conditions because of the difficulty of manipulating soil communities in the field.

The buccal ganglia were stained with glyoxylic acid only due to the difficulty of manipulating them for the antiserum treatment.

Our ability to disentangle the roles of extrinsic and intrinsic factors in driving carryover effects is undermined by the difficulty of manipulating these factors independently in wild populations [ 1], but see [ 4].

Because of the technical difficulties of manipulating complicated scenic effects (e.g., storms, forest fires, and earthquakes), the star actor was eventually obliged to hand over artistic control to a neutral observer, the stage manager, who could coordinate all aspects of the production.

Due to the difficulties of manipulating the mouse preimplantation embryo, there has not been any study using securin degradation to study SAC activity in this system.

Despite intense study, many crucial details concerning the mechanism of this coupled reaction are still largely unknown and disputed [21], [22], primarily because of the difficulty of experimentally manipulating the large membrane-imbedded CO polypeptide.

Functional studies in HaeBPF have been hampered by the difficulty of genetically manipulating these strains, a difficulty that genomics does not explain.

Recognizing the difficulties concerning the possibility of manipulating private information by individuals, the literature has verified that this incentive problem could be dealt with by the planning procedures that require a continuous revelation of information, provided that agents adopt myopic behavior.