Sentence examples for difficulty of investigating the from inspiring English sources
The 5-hmC concentration in mammalian genomic nucleotide bases was less than 1% (Kriaucionis and Heintz, 2009), and traditional bisulfite sequencing methods could not distinguish 5-hmCs from 5-mCs (Huang et al., 2010), which increased the difficulty of investigating the biological functions of 5-hmCs.
The challenge for discovering control mechanisms lies in the difficulty of investigating the cumulus-oocyte complex which is a developmental unit, implying that oocytes in isolation do not faithfully reflect biology in situ.
The intentions of the Social Service Act are carried out by each municipal social welfare committee and they now face the difficulty of investigating the individual needs of the family caregivers, the kind of help and support they demand, and also to investigate the effects of different interventions.
One severe difficulty for investigating the roles of calcium is that many microorganisms, including the model filamentous ascomycete fungus Aspergillus nidulans, require only minute quantities of calcium, easily satisfied by trace contamination of media components.
The archdiocese released only the summary of the report prepared by a lawyer, Marion Westpfahl, but even that made clear the difficulty of investigating molestation cases in the church, where an atmosphere of secrecy reigned.
The functional consequences of some viral protein caspase cleavages still remain debated or elusive because of the difficulty of investigating hazardous entities (influenza, HCV), the multitude of strains and genotypes (influenza, HCV, adenovirus) or the lack of appropriate tools such as cellular or animal models allowing to recapitulate the viral life cycle (TGEV, MCV).
The situation reflected the difficulty of investigating a highly technical incident involving three major companies — Boeing; Thales, a French electrical-component maker; and GS Yuasa, the Japanese battery maker — on three different continents whose representatives all speak different languages.
A major drawback in coronary atherosclerosis (ATS) research is the difficulty of investigating early phase of plaque growth and related features in the clinical context.
In part, this can be attributed to the difficulty of investigating secondary growth in situ in a non-invasive manner, in part to the relatively big scale of the process.
The sclerocytes that build spicules have multiple nuclei, and in glass sponge larvae they are connected to other tissues by cytoplasm bridges; such connections between sclerocytes have not so far been found in adults, but this may simply reflect the difficulty of investigating such small-scale features.
It also emphasizes the difficulty of investigating chemotherapy resistance in ovarian cancer.
