"Between the Lines" begins with a note from Picoult, gushing about her now-16-year-old daughter's creativity and the difficulties of harnessing it after Samantha van Leer first approached her mother with the basic idea that became "Between the Lines": What if a fairy tale's characters lived entirely different lives after the book's cover was closed?
One important aspect of heterosis is the difficulty of fixing the favorable properties of the hybrids into a true breeding line, making repeated crosses from inbred lines the most practicable method of harnessing the benefits of heterosis.
Professionally-led groups can address these potential difficulties while also harnessing the potential benefits of peer support and interactions, and have also been found to be effective in other areas such as cardiac and pulmonary rehabilitation [ 51- 53].
The analysis of the challenges ahead the likely military threats, the need to harness new technologies and the difficulty of "re-engineering" America's huge defence bureaucracy is pertinent and shrewd.
Grant, who worked with Essien when he was coach of Chelsea and with Boateng when he was in charge of Portsmouth, is keen to harness the country's top talent, especially given the difficulty of the group they have been drawn in for next year's Africa Cup of Nations.
However, next generation sequencing technologies have not yet been fully harnessed for the study of vector-borne and zoonotic pathogens, due to the difficulty of obtaining high-quality pathogen sequence data directly from field specimens with a high ratio of host to pathogen DNA.
"The difficulty of correlating,….
The difficulty of baseball is imperious".
Difficulty of integration.
Hence the difficulty of replication.
