Sentence examples for difficulty of functional from inspiring English sources
Considering that sequence variants in the noncoding region may also affect the regulation and function of genes and the difficulty of functional characterisation of various CYP1B1 isoforms in vitro, analysing multiple SNPs simultaneously may provide more direct evidence for the relationship between cancer risk and the genetic polymorphisms in CYP1B1.
When the uniseqs were queried against the nr protein database, about 76.2% of them had no significant homology with proteins of known functions, which may be related to the difficulty of functional characterization of genes in rust fungi.
Large bone defect treatment represents a great challenge due to the difficulty of functional and esthetic reconstruction.
The second issue is that few neurons actually mature in the lesion, which would account for the difficulty of functional recovery after ischemic injury.
The Gene Ontology (GO) addresses the difficulty of functional classification for gene products, and has become the main resource for capturing such information in a controlled format that can be effectively used for search and computational analysis (1, 2).
A new debate over the costs and benefits of deploying the military reflects the length of the conflicts in Afghanistan and Iraq, the difficulty of building functional governments and the financial burden at home in a time of extreme fiscal pressure.
To overcome the difficulty of adding functional groups to PCU, we explored various surface modification methods, and determined that plasma treatment was the most effective method to modify the graft surface with functional amine groups, which were subsequently employed to conjugate heparin via end-point immobilization.
However comparative biology both within avian species and within amniotes is hampered due to the difficulty of recognising functional orthologs.
In this study, we investigated and compared different statistical and machine learning approaches to integrate multiple types of information to overcome the difficulty of identifying functional ERα/SRC-1 interaction in presence of weak ChIP-seq signal.
We also highlight the limitations and challenges of research in this area, including the difficulty of defining functional decline, a necessary component for a dementia diagnosis, the lack of normative neuropsychological data, and other shortcomings inherent in existing diagnostic criteria.
