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The company's total production has barely budged since 2002, despite some major acquisitions, because of declines in older fields and the difficulty of exploring for new fields in a world where most oil is now controlled by national oil companies.
One hurdle that has long faced teachers trying to incorporate macroevolution into their curricula is the difficulty of exploring the subject with hands-on, organism-centric labs.
This is largely due to the difficulty of exploring an immense conformational space to identify the set of conformers that collectively best fits the experimental diffraction pattern.
In the marine brown macroalgae, the morphological characters are highly similar between two widely distributed genera, Homoeostrichus and Zonaria (Dictyotaceae), thereby resulting in the difficulty of exploring their hidden biodiversity.
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The harrowing difficulties of exploring the wreck unfold along with this mystery, with the group of divers tragically narrowing -- three are killed -- as the submarine stubbornly refuses to yield its secrets.
At first glance this appears surprising but could be explained by the technical difficulties of exploring a field where conditioned and conditioning stimuli overlap and vary in the same direction.
Given this difficulty of thoroughly exploring the chemical-space of drug like molecules, fragment-based approaches have emerged.
The purpose of the method is to guide the individual through a process of exploring difficulties in living with an illness systematically and creatively by means of words and drawings and then to focus on which difficulties to change in order to develop internally motivated self-management of the illness [ 24].
There are many reasons for this, ranging from the underestimation of depressive symptoms by clinicians, their widespread presence in the context of cancer, the entanglement of depressive symptoms with those associated with the cancer and its treatment, or, indeed, the difficulty of clinicians in exploring emotional symptoms [1,2].
The principal difficulty in exploring this bounty is keeping up with the emergence of new producers and new vineyard regions.
Previous work has shown that the continuous solver differential evolution (DE) can be successfully applied to this discrete problem, but has difficulty exploring the region of solutions with lowest resonant frequency.
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