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Due to the difficulty of examining the process of calcite nucleation on natural matrices such as Synechococcus S-layers, a very recent review focused on studies of nucleation at carboxyl-terminated alkane thiol SAM surfaces on noble metal substrates.
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Most of the studies addressing the fate of APs and BPs by time-lapse imaging have been carried out at later stages of neurogenesis, due to the technical difficulties of examining these progenitors at the very onset of neurogenesis.
This result illustrates the difficulty of examining changes that could potentially occur at any time during the development of the breast and thus affect anything from a single cell to the whole organ.
The reason for this neglect may be either the perception that primary teeth are not as important as the permanent counterparts or the inaccessibility and difficulty of examining such young children.
Smoking is such a strong risk factor of lung cancer (IARC, 2004) that its presence makes it difficulty to examine the effects of occupational exposures with weak to moderate carcinogenicity.
Typically, deletion of these proteins leads to the abolishment of large PPI networks, highlighting the difficulty in examining the contributions of specific interactions/activities to complex biological processes and cell phenotypes.
Our findings underscored the difficulty in examining the performance of non-practiced participants.
Survey items were analyzed for item difficulty by examining the percentage of participants that answered each item correctly.
We assessed how 'well' the items performed (discrimination and difficulty) by examining the consistency of response patterns across countries using the full international dataset.
A difficulty with examining the effectiveness of copper targeting in cell culture models is that cultured cancer cells seem to possess low to trace levels of copper [ 42].
This represents the difficulties of examining interventions related to education and training.
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CEO of Professional Science Editing for Scientists @ prosciediting.com