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This reality of the difficulty of effective use is often dismissed by the general public because of the simple ease of use.
However, the development of drought-tolerant varieties still represents a challenging task, being hampered by the occurrence of genotype × environment interactions, the difficulty of effective drought tolerance screening and a still partial understanding of the molecular mechanisms of plant drought tolerance (Richards 1996; Kumar et al. 2008).
The Institute of Medicine's report, Crossing the Quality Chasm: A New Health System for the 21st Century, summarized the difficulty of effective implementation and diffusion of proven health-care interventions (41).
Although the recent study theoretically emphasises the difficulty of effective border control (including quarantine) [ 35], we stress that the epidemiologic characteristics of influenza (e.g., short incubation period and generation time) permit anticipating large ripple benefits from quarantine (given that importation may continue for only a short period of time before full border closure occurs).
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And it emphasises the administrative difficulties of effective income taxation.
Changing the law remains controversial, with groups including the British Medical Association opposing legalisation of assisted suicide or voluntary euthanasia, on the grounds that "it is alien to the traditional ethos and moral focus of medicine" and because of the difficulties of effective monitoring.
Managerial role in the practice of CSR is limited and ineffective in Ghana and difficulties of effective CSR implementation mainly stem from weak leadership due to mismanagement and corruption.
This nosocomial transmission occurred despite heightened awareness during this pandemic, which demonstrates the difficulties of effective containment in the hospital setting (28, 29 ).
"These problems are compounded by the difficulty of making effective disclosure to shareholders about the cost of the practice".
There would not be fury at those responsible for the disaster, nor would there be frustration about the evident difficulty of mounting effective reprisals, as there is now.
It was in part the difficulty of making effective replacements that led the creators of "The Full Monty" to ensure that the new musical was essentially replacement-proof by featuring a strong ensemble cast but no big names, along the lines of "Cats" or "Les Misérables".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com