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Given the (i) multi-domain nature of many protein kinases, (ii) difficulty of domain assignment, and (iii) existence of domain shuffling, we wished to propose a protocol to refine classification that would: take into account full-length sequences, be insensitive to domain detection inaccuracies by avoiding the step of domain detection, take into account domain shuffling.
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The results showed that item difficulties of each domain, especially those in the Activity domain were hierarchically ordered along the logit metric (see Table 2).
Then, the difficulties of the domain of attraction confronted in system analysis and synthesis can be overcome.
But because of the difficulty of calculation, open domain problems are often simplified as equivalent model in the finite space in order to save time of modeling and analyzing in the computer.
Finally, as we have seen, the main issue that was encountered during the development of both the datasets and application was the difficulty of communicating to domain experts the distinction between human judgement and the mechanical application of modus ponens.
Sdev and Smod results within each similarity range are consistent across most alignment methods (Fig. 2), pointing to the inherent ease or difficulty of aligning particular domains.
The possible score for each item within a domain ranged from 1: unable to do to 5: able to do without any difficulty ¥ Proportion of consumers who scored 1 to 4 indicating any level of difficulty difficulty with domain items; § Proportion of consumers who scored 5, indicating no difficulty with domain items.
Constructing virtual 3D historical scenes from literature and records is a very challenging problem due to the difficulty in incorporating different types of domain knowledge into the modeling system.
Where cross-domain dual tasks costs have been observed, increasing difficulty of Task A in one domain results in decreased performance on both Task A and concurrent Task B in some other domain.
Caregivers respond to questions on a 5-point Likert-type scale about frequency and difficulty of events in the domains of communication, emotional functioning, medical care, and role function.
For example, the person item maps of the "difficulty" domain (factor 2) suggest that our instruments perhaps cover patients with greater difficulty in physical activity than the difficulty shown by patients in our sample, since the person distribution is skewed to the lower end of the scale.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com