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One major difficulty of disease subtype discovery using multi-omics data is the possible heterogeneity of clustering results from different omics data.
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Nevertheless, because of the indiscriminate nature of these weapons—as well as the potential for starting widespread pandemics, the difficulty of controlling disease effects, and the simple fear that they inspire most countries have agreed to ban the entire class.
However, the difficulty of determining disease activity and fibrosis by serologic and biochemical data in chronic hepatitis B makes liver biopsy an important tool in the management of a subset of patients.
One reason for the lack of empirical evidence in natural systems is the inherent difficulty of matching disease data with variation in host density in either space or time.
This complexity lies at the core of the difficulty of unraveling disease pathogenesis.
The difficulty of determining disease activity is further compounded in multicenter trials, as definitions may not be universal between investigators.
Eventually, prevalence in deer may become too low to accurately estimate through current methods because of the difficulty and expense of obtaining a sufficient sample size, and consequent difficulty of verifying disease eradication.
Linfa Wang knows all about the difficulty of naming diseases.
The surveillance tool may provide a solution to the difficulties of measuring disease incidence that are faced for many causes of febrile illness (22 ).
I share how I have coped with the difficulties of HIV disease and medical treatment and provide anticipatory guidance and support they need.
We discuss the difficulties of measuring disease burden, medical care complexities, waning international support, and research and development barriers for HAT.
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