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This change of strategy was provoked by the increasing complexity and difficulty of discovering and developing new drugs and by skyrocketing drug-development costs.
As Russell himself put it in 1909 "the difficulty of discovering the truth does not prove that there is no truth to be discovered" (Philosophical Essays: 20/Papers 6: 20/Papers
Plaintiffs will encounter at least three substantial deterrents: expense, time, and the difficulty of discovering substantial incriminating evidence before a complaint is even filed.
In view of the difficulty of discovering uncommon alleles, and the large effect of allele misclassification on power [7], this second benefit may often be important.
In addition to this difficulty of discovering SNPs are the difficulties of SNP scoring in a tetraploid genome.
Indeed, it is the difficulty of discovering or even conceiving of mechanisms of directed adaptive change in genomes that have for decades relegated the Lamarckian scheme to trash heap of history.
Similar(54)
It is indeed a matter of great difficulty to discover [cognoscere], and effectually to distinguish [actu discriminare], the true motions of particular bodies from the apparent; because the parts of that immovable space, in which those motions are performed, do by no means come under the observation of our senses [incurrent in sensus].
The awe of discovering the human body.
It's a whole process of discovering.
Having difficulty in discovering the exact position of the French batteries, the German cruisers soon turned their attention to the French shipping in the harbor.
Despite the use of well-defined formal metadata for LOs, the users of the LOs (that is, teachers and students) are facing difficulties to discover and find suitable LOs from LORs (Hyon, 2011; Dahl & Vossen, 2008; Al-Khalifa & Davis, 2007).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com