The response decreased with the increase of wall thickness, which should be ascribed to the increasing difficulty of gas diffusion to the inner of the walls.
Low substrate moisture content also resulted in secondary metabolite formation due to the difficulty of solute diffusion to the cells of microorganisms during SSF [ 28].
In addition to an inherent blood tissue glucose lag, progression of the FBR increases the difficulty of glucose diffusion to the sensor.
Zhao et al. [5] who grow Si nano-flowers on Si(100) substrates with cooling facility for the substrate to keep the substrate temperature fixed at 4°C during deposition also encountered such difficulty, while diffusion of Si adatoms on the Si substrate is much less than Ag adatoms on glass substrates.
In order to obtain the necessary uniform estimates and overcome the difficulty of a singular diffusion term, the entropy functional method is used.
The discrepancy between observers 3 and 4 and observers 1 and 2 regarding sensitivity, specificity, PPV, NPV, and diagnostic accuracy is mainly attributable to the lower level of expertise and to the difficulty in interpreting diffusion images of middle ear cavity.
The poorer performance of the MOFs with higher Pd loadings may be explained by an increased difficulty in the diffusion of the substrates and the products through these materials, owing to pore blocking.
Due to the difficulty of experimentally measuring the diffusion coefficient of receptor ligand complexes, we have not been able to find measured values for this quantity.
The Institute of Medicine's report, Crossing the Quality Chasm: A New Health System for the 21st Century, summarized the difficulty of effective implementation and diffusion of proven health-care interventions (41).
The difficulty here is the physical properties of diffusion.
Moreover, some difficulties and drawbacks of diffusion-based compression for arbitrary images do not apply to this special case.
