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The secretin story shines a light on the difficulty of developing a drug for autism, an often debilitating condition whose incidence seems to be rising sharply and for which there are no approved drugs.
And given the difficulty of developing a game for three different platforms, they are deciding to drop support for Linux.
However, because of the difficulty of developing a consistent and conceptually transparent theory of quantum gravity, so far this suggestion has not been developed beyond the stage of a simple intuition.
However, the surface proteins on the four serotypes of dengue virus display high variation, which increases the difficulty of developing a vaccine that can protect against all viral strains.
Previous studies highlight the importance and difficulty of developing a business case for quality improvement.
This highlights the difficulty of developing a complex physiotherapy exercise intervention.
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Having served as a conferee in 2002, I appreciate the difficulty of developing an acceptable bill that fulfills divergent perspectives; however, the fierce partisanship delayed the opportunity to find the best policy solution.
Hopes of totally controlling the disease have been dramatically dampened because of a number of factors, including the difficulty of developing an effective vaccine, the expensive and time-consuming diagnostic process, the necessity of many months of treatment, the increase in HIV-associated tuberculosis, and the emergence of drug-resistant cases in the 1980s.
One reason why HCV remains a major public health threat is the difficulty of developing an effective treatment strategy because HCV is characterized by long episodes during which the patient is asymptomatic, even after liver damage has occurred.
Despite the difficulty of developing an adequate measure to calculate the similarity matrix containing inter-relationship information between miRNA and gene expression, we implemented 4 measures, GR_1, GR_2, GR_3, and GR_4, and compared with the proposed method, GR_5, in order to assess the benefit of the proposed one.
To mitigate the difficulties of developing a cyberinfrastructure, this study proposes a new computing paradigm: Cyberinfrastructure as a Service (CaaS), i.e., providing a service to enable building a cyberinfrastructure on demand.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com