For pharmacology, Shen wrote of the difficulties of adequate diagnosis and therapy, as well as the proper selection, preparation, and administration of drugs.
They achieve the latter quality with diminishing success in view of the vastly increased number of publications that daily appear throughout the world, the failure of publishers to provide legal-deposit copies, and the difficulty of ensuring adequate representation of publications issued in the developing countries.
The application of cell-based therapies in regenerative medicine is hindered by the difficulty of acquiring adequate numbers of competent cells.
The discussion on the difficulty of finding adequate content in students' mother tongue raises the question of what should be done to improve the situation.
The official history of the USAAF judged that the difficulty of transporting adequate supplies to India and China was the most important factor behind the failure of Operation Matterhorn, though technical problems with the B-29s and the inexperience of their crews also hindered the campaign.
This illustrates the difficulty of obtaining adequate "non-LTR" control sequences.
By April 1932, Lewis Weed had abandoned the project, "reason being insuperable difficulty of securing adequate funds for this development".
The difficulty of obtaining adequate numbers of disease-free and age and sex matched controls has been a problem in previous investigations, especially in an elderly population.
The Table also highlights the difficulty of developing adequate surveillance systems and therefore the difficulty of accurately estimating morbidity and mortality rates for human populations in resource-poor settings.
However, cellular therapy using MSCs has obstacles, including: the difficulty of obtaining adequate numbers of these cells to transplant; adverse effects of the cells or concomitant immunosuppressive therapies; and the possibility of infection by opportunistic microorganisms [ 13- 15].
