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Whereas the calculation for KM2P looks deceptively simple (Table 1, Figure 1), delineating search areas has to be done algorithmically when the number of samples is realistically large and this difficulty needs to be considered beforehand.
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Other difficulties needed to be solved, too.
-What difficulties need to be addressed in order to have smooth elections?
The phrase originally referred to studies by the National Institute of Child Health and Human Development, finding that children with reading difficulties needed to learn phonics.
But people with emotional health difficulties need to trust that we will be there for appointments before they will talk about their anxieties.
These difficulties need to be solved by careful design and long-term tests for verification.
Interventions aimed at reducing behaviour difficulties need to consider the impact of multiple risk variables.
The method for obtaining layer solutions in [2] and [3] cannot be used in our case directly; some difficulties need to be solved.
The additional difficulties needed to be overcome for applicability in space include radiation hardness for total ionizing dose and single event effects (SEE), and reliability.
MHC class II restricted neoantigen has the potential to be a promising target of tumor immunotherapy, although the limited comprehension and technical difficulties need to be overcome before being applied into clinical practice.
During the design and construction of the beamline, many technical difficulties needed to be solved because of its high energy resolution, high photon flux and high focusing quality, including the design of monochromator, the design of Kirkpatrick Baez (KB) mirror system and the manufacture of the optics.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com