Yet it also has a number of drawbacks, including the deficiency for physical interpretations of results, and difficulties in tuning the training and iteration parameters.
At present, no M2 blocker is active against both wild type and all circulating M2-mutant strains, likely due to difficulties in tuning the structure of small molecule-based inhibitors to fit each of the individual mutant M2 ion channel proteins.
Because of the difficulties in tuning, a genetic algorithm is implemented off-line to obtain optimal observer parameters for the DAO.
Because of these difficulties in electric tuning of the standard cholesterics, their use as materials for electrically tunable large-area smart windows, mirrors, filters, displays, and lasers are not currently feasible.
Patients with sensory hypersensitivity have difficulty tuning out otherwise neutral stimuli such as the tag in their shirt or the voices of people around them.
Mitsuda expressed difficulty in selecting the tune for the orchestral medley, eventually picking a tune from each era and certain character themes.
Mr Cheney's office had difficulty in getting chosen reporters to tune into its arguments; indeed, but for Mr Cheney worrying at it like a dog at a bone, Mr Wilson's article would have been long forgotten.One possible explanation is that Mr Cheney knew that the administration's claims about WMD were false.
Figuring out how to tune the difficulty in Unify was all about learning what makes puzzle games work, both in [terms of] the games, and in [terms of] the players.
The Institute of International Finance was more guarded, saying that, "the difficulties inherent in fine-tuning the Chinese economy suggest that the adjustment to more moderate growth is likely to be bumpy with implications for the rest of the region and the world".
