Sentence examples for difficulty in trial from inspiring English sources

A lack of validated measures of outcome and uncertainty regarding the appropriate disease states in which to test these agents have led to difficulty in trial design.

The fundamental problem has been difficulty in trial design with many of the challenges carrying over from clinical trials to clinical practice.

There have been only 3 drug approvals for NMIBC in the last 30 years, and product development for this disease has been stymied by difficulties in trial design and patient accrual.

The successful accomplishment of future H&N cancer treatment trials will need to acknowledge the increasing use of IMRT despite inherent difficulties in trial design and quality assurance.

There has been extensive analysis of screening mammography effectiveness (e.g. methodological difficulties in trial project and analysis, selective detection of certain types of tumours and breast cancer over-diagnosis) [ 9].

However, we know that one of the major difficulties in trials which randomise people to follow specific dietary patterns is that any particular diet cannot possibly suit every individual, which undoubtedly influences adherence.

High-risk patients with advanced disease, including critical limb ischemia (CLI), are often excluded leading to difficulty in translating trial results into real-world clinical practice.

The difficulty in designing trials is reviewed, including the choice of the time point in the cycle to randomize patients, how to account for all the patients and embyros that are involved in the trial, whether to incorporate prenatal genetic screening, and the best type of study design to address the risk/benefit ratio of these practices.

Another difficulty in clinical trials with patients with FD is the remarkable placebo response.

With regard to disease heterogeneity, a major difficulty in designing trials of disease-modifying therapy in neurodegenerative diseases is lack of diagnostic confidence, particularly at a stage of disease evolution when intervention is likely to be most effective.

Clinicians and data managers often report difficulty in explaining trials, and audio/video-tape audits show that critical information is often omitted or poorly presented during consent interviews (Jenkins et al, 1999; Loh et al, 2002).