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For conservatives who are suspicious about the government's ability to enact useful social policy, the study highlights the difficulty in targeting government programs to those who are most likely to benefit, rather than those most likely to seek them out.
Another challenge in HIFU for HCC treatment is the difficulty in targeting and monitoring since the liver is subject to respiratory movements.
Meanwhile, in order to translate in vitro synergistic effects of two kinds of drugs into the clinic, a delivery system that can deliver the both drugs and release them in time-differential manner is essential due to the difference between pharmacokinetic (PK) properties of the drugs and the difficulty in targeting the same cancer cells in proper temporal sequence [13 16].
These results on the dual drug-encapsulated nanoliposome system can contribute to translation of in vitro synergistic effects of two kinds of drugs into the clinic through overcoming both the difference between PK properties of each drug and the difficulty in targeting the same cancer cells in proper temporal sequence.
The delay in developing such a model owes largely to controversy over the identity of the cell type of origin of BRCA1-associated inherited invasive EOC and the resultant difficulty in targeting molecular alterations to the correct cell type.
Whilst detection of prostate cancer may be more difficult amongst obese men, the treatment received by those obese patients who do develop prostate cancer may be less effective than that received by non-obese patients, for example, as a result of technical difficulties during surgery [17] or difficulty in targeting radiotherapy [18].
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While optogenetics is continuing to enable novel studies that were previously impossible, a number of fundamental limitations exist, including lack of deep tissue penetration using conventional visible light sources, the need for invasive surgeries to deliver light, and difficulties in targeting deeper brain regions [43].
White House officials and some technology experts warn both of the risks and the difficulties in targeting specific hackers without causing widespread spillover.
Treatment may be complicated by poor compliance, difficulties in targeting insulin therapy and concerns about weight gain [ 94].
This article examines the current misunderstandings and the main difficulties in targeted drug delivery.
The low content of boron targeting species in glioblastoma multiforme accounts for the difficulty in selective targeting of this very malignant cerebral tumor by this radiation modality.
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