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The molecular mechanisms of cork formation are still poorly understood, in great part due to the difficulty in studying a species with a long life-cycle and for which there is scarce molecular/genomic information.
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The lack of association between some of the known transmission risk factors and HCV positivity, not just in our study but in many others [ 14, 15, 21, 22], highlights the difficulty in studying an often asymptomatic disease where the time point and source of infection are difficult to identify.
The inherent difficulties in studying a complex, low base rate behavior with negative connotations have stimulated methodological diversity.
There are some difficulties in studying an entity that has not yet been clearly defined.
However, a major difficulty in studying multisite phosphorylation from a system's perspective has been the uncertainty whether simultaneous or successive phosphorylation occurred at the different sites on the same protein and whether the multiple sites were phosphorylated by the same or different protein kinases.
A difficulty in studying cancer at early stages is that the tumor size is small and only limited material can be obtained through means such as fine needle aspiration.
Characterizing the set of such equilibria is a key difficulty in studying this problem.
A technical difficulty in studying the solvability problem led us to finding another method for getting solutions in [20].
A major difficulty in studying chemotactic behavior of V. alginolyticus is that the classical rotation assay [6], [7] that has been used successfully for E. coli cannot be reliably applied to this marine bacterium.
A major difficulty in studying the origin of eusociality is choosing the right study system.
A major difficulty in studying pancreatic ductal adenocarcinoma (PDAC) biology is represented by the peculiar morphologic traits of the tumor.
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CEO of Professional Science Editing for Scientists @ prosciediting.com