Even for arbitrary BRNs, such as this one, different sets of logical parameters can be inferred, leading to difficulties in selection of the parameters.
Nagel (p. 10) cites Michael Behe's (1996) Darwin's Black Box, with approval, not because he accepts intelligent design, but because he believes Behe points out seemingly insuperable difficulties in selection theory.
Main uncertainties related to the difficulties in selection of end points, thresholds, and very limited epidemiological data at prevailing exposure levels.
Another source of difficulty in the selection of the PBD-design amplitudes occurs when the standard spectrum shape is not capable of describing excitation from large distant earthquakes.
However, users pointed out several usability and technical issues such as difficulty in mode selection and lack of sophisticated surface modeling tools as some of the key limitations of the current system.
NMR samples can be run in minutes, yielding both proton and 2D-HSQC spectrums from a single sample, while eliminating difficulty in solvent selection and standard solutions.
However, the exponential availability of medical articles leads to difficulty in the selection of articles and reading the full version of an article is time-consuming.
For clinical research itself, this may translate into a decrease in the number of patients recruited in clinical trials and in a difficulty in controlling selection bias.
Although this offers an unprecedented opportunity for cross-species comparison and translation (Poussin et al., 2014), it also adds complexity and difficulty in model selection for preclinical studies.
