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These methods account for the material properties in computation, which may lead to difficulty in operations of matrices and control of (stable) convergence.
On the other hand, the popular microplate technology, which has a great merit of being able to perform parallel multistep reactions, has come to its limit in increasing the number of wells (currently, up to 9600) and reducing the volume to deal with due to the difficulty in operations.
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This can reduce some signaling complexity but increases the difficulty in operation.
It has been found that seeking further internal heat integration can sometimes improve process dynamics and lessen difficulties in process operation.
Special caution should, however, be taken when the latent heat of the distillates is to be recovered within/between the ideal HIDiCs involved, because a positive feedback mechanism may be formed and give rise to additional difficulties in process operation.
Currently, the number of wells per micro-plate has boosted up to almost the limit of 3456 to 9600 with increase of difficulties in operation time and throughput accuracy [ 24].
Because the group was fully skilled and effective in treating degenerative spinal disease by TLIF, we didn't encounter any difficulty in the operation process.
Capital needs: Its difficulty in scaling operations so far has an expensive consequence.
This may result in the formation of icelike gas hydrates, which can cause difficulty in plant operation and must be prevented from forming in order to avoid problems in subsequent transportation.
Atmospheric conditions (e.g., wind speed) are the prime cause of difficulties in flight operations.
By contrast, the pace of layoffs may accelerate when that company faces difficulties in business operations or a weakening market.
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CEO of Professional Science Editing for Scientists @ prosciediting.com