These methods account for the material properties in computation, which may lead to difficulty in operations of matrices and control of (stable) convergence.
On the other hand, the popular microplate technology, which has a great merit of being able to perform parallel multistep reactions, has come to its limit in increasing the number of wells (currently, up to 9600) and reducing the volume to deal with due to the difficulty in operations.
Currently, the number of wells per micro-plate has boosted up to almost the limit of 3456 to 9600 with increase of difficulties in operation time and throughput accuracy [ 24].
It has been found that seeking further internal heat integration can sometimes improve process dynamics and lessen difficulties in process operation.
Special caution should, however, be taken when the latent heat of the distillates is to be recovered within/between the ideal HIDiCs involved, because a positive feedback mechanism may be formed and give rise to additional difficulties in process operation.
Because the group was fully skilled and effective in treating degenerative spinal disease by TLIF, we didn't encounter any difficulty in the operation process.
This may result in the formation of icelike gas hydrates, which can cause difficulty in plant operation and must be prevented from forming in order to avoid problems in subsequent transportation.
Capital needs: Its difficulty in scaling operations so far has an expensive consequence.
Large size of the device imposes certain difficulties in the operation, such as access of the diagnostics, manual control of subsystems and large number of signals monitoring etc.
Despite various difficulties in their operation and maintenance, the advantages offered by coextrusion encouraged R&D efforts by processors, material suppliers, and equipment manufactures.
