Sentence examples for difficulty in inducing from inspiring English sources
No broadly protective ETEC vaccine is available, largely because of the difficulty in inducing immunity to the small ST molecule.
Until recently, the reasons for difficulty in inducing such bnAbs have been obscure.
Under the direction of Gerry Anderson, who wanted to compensate for the inadequacies of Supermarionation (such as the difficulty in inducing lifelike arm and leg movements) and increase the realism of the format, The Secret Service incorporates footage of live actors for long-distance shots.
Although var2CSA is the most promising current PfEMP1 vaccine candidate because it is relatively well-conserved across strains, the difficulty in inducing effective adhesion-blocking antibodies remains an obstacle.
In a previous study, we experienced difficulty in inducing ASP-RNAi against the London-type amyloid precursor protein (APP) mutants, in which single nucleotide substitutions followed by amino acid substitutions (V717I, V717L, V717G) were present [17].
This difficulty in inducing advanced lesions in rodent and rabbit models is in stark contrast to the prevalence of severe atherosclerosis in humans, which occurs even in some individuals with mildly elevated LDL levels and no other obvious risk factors (Vasan et al. 2005).
It also shows the difficulties in inducing strong T cell responses with this approach.
Technical difficulties in inducing c-fos expression within trigeminal nucleus caudalis are also important [49].
However, multivalent DENV candidate vaccine trials have been severely hampered by difficulties in inducing a balanced serotype-specific immune responses in vaccinees [37].
Because of ethical difficulties in inducing nicotine dependence in naïve human subjects, we explored reinforcing effects of nicotine in experimentally-naive non-human primates given access to nicotine for periods of time up to two years.
In addition, humans have no pre-existing immunity to H5 viruses upon which to build, which may have contributed to the initial difficulty seen in inducing seroconversion to H5-based subunit and killed virus vaccines [4], [5], [6].
