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However, since it required complicated electrode structures, they had difficulty in improving the recovery rate and reproducibility.
Our cryo-EM analysis revealed a strong heterogeneous conformation of the dimeric mTORC1 with the distance between edges of two kinase domains ranging from 9 Å to 29 Å even after the mTORC1 cryo-EM sample was generated with mild glutaraldehyde gradient fixation (Fig. S3), which explains the difficulty in improving the resolution of mTORC1 reconstruction.
Owing to the difficulty in improving the catalytic activity of Rubisco, we attempted to increase the substrate supply (RuBP or CO2) for Rubisco to drive the reaction forward.
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The difficulties in improving the availability, reliability, and accuracy of these indoor capable GNSS receivers exceed those of the receivers designed for the most hostile urban canyon environments.
The existing computer aided diagnosis (CAD) methods used to benefit a lot from low-level or middle-level features which are not that good at the simulation of real diagnostic processes, adding difficulties in improving the classification performance.
If authors do not consider key methodological features at the design and execution phases of their study, they will have difficulties in improving the paper at the later scientific phases.
However, major difficulties still exist in improving the yield of acarbose, leading to a high cost for its manufacture.
These recent studies highlight the difficulty in improving clinical practice and underscore the need for improved educational interventions.
66 Given the difficulty in improving functional outcomes following traditional strength training interventions, the addition of anaerobic training may lead to increased mobility and agility that is important for activities in daily living such as climbing stairs and walking over different terrain.
Dr. Wachter said the study made clear the difficulty in improving patients' safety.
The difficulty in improving conditions for Palestinians, Mr. Sharon said today, is that "once we open the siege and things like that, we immediately have casualties".
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