Sentence examples for difficulty in extrapolating the from inspiring English sources

These differences highlight the difficulty in extrapolating the results of randomized clinical trials of ICDs into general clinical practice.

A lack of information on external validity items and well-defined outcomes can lead to difficulties in extrapolating the results of a study to other MO-patients with forearm deformities.

Difficulties exist in extrapolating the rat data to other species because biliary excretion does not scale uniformly, as shown in studies with therapeutics (Mahmood and Sahajwalla 2002).

However, this study is limited by the relatively small cohort size in each category and there is inherent difficulty in extrapolating these data to draw conclusions on genotype phenotype correlation.

A clinical trial may answer a specific question, but as a consequence of limited surgeon involvement and a restricted patient population, there may be difficulty in extrapolating these findings to community practice in order to achieve a beneficial outcome.

Overall, the study highlights the inherent difficulty in extrapolating ARI estimates beyond the range of the available historical record.

The advantage of a direct comparison between the material and mechanical properties is counterbalanced by the difficulty in extrapolating to more general results at the macroscopic scale, since single trabeculae are not isolated entities in physiological conditions.

Another concern about the calculation of dioxin-like potencies in epidemiologic studies relates to the difficulty in extrapolating from rat to human, given that large differences in AhR-mediated gene expression and EROD activity are observed even comparing rats with mice [ 95].

The difficulties in extrapolating into the low-dose region of dose--response curves are pointed out.

General inferences that can be made from this study are limited because of the difficulties in extrapolating from one health-care system to another.

This type of experiment is useful for studying complex mixtures, or on a case-by-case basis, but leads to difficulties in extrapolating from one mixture to the other because small variations in composition may lead to significant changes in its toxic effects.