As this expanded Incremental model is predominantly based on the same data as was used in the estimation of Vm, the source of variability is easily attributed to the difficulty in characterizing the proximal deposits with one measurement.
The nature of the denatured state ensemble has been controversial for decades owing, in large part, to the difficulty in characterizing the structure and energetics of denatured state interactions.
This heterogeneity has contributed to difficulty in characterizing the inter-relationships among FM clinical features and in determining the importance of various comorbidities to patients and their treatment outcomes.
The difficulty in characterizing the molecular mechanisms of AFPs arises largely due to their unusual relationship with water, which in this case serves as both the protein's solvent and, as ice, its target (Jia and Davies, 2002).
Often, the correlation between cue diversity, evolution, and mating cannot be made directly due to the difficulty in characterizing the mating cue, identifying the gene(s) giving rise to the (often extremely complex) chemical signal, and conducting mate recognition studies in the same populations.
To compound the difficulty in characterizing the central timer, physiological studies have shown that these single-celled organisms actually contain two different endogenous clocks, as the rhythms of bioluminescence and swimming behavior can run with different periods [ 14] and show different phase resetting behavior [ 15].
Several recent technological breakthroughs have eliminated two fundamental difficulties in characterizing the relationship between pre-AUG AN and translation efficiency in S. cerevisiae.
In these cases, identifying the exact mechanism is a complex task owing to a still limited knowledge on non-homology based pathways and to difficulties in characterizing the variants at the sequence level.
Although distinct properties of cancer metabolism known as Warburg effects have been examined mainly in cultured systems or conventional animal experiments, there are several technical difficulties in characterizing the metabolism of human solid tumors in vivo.
We are just beginning to learn what role these dynamics play in the mechanism of chemical catalysis by enzymes due to extraordinary difficulties in characterizing the conformational space, that is, the energy landscape, of a folded protein.
With the initial interpretations of these Gram stains as gram-variable, which resulted in misidentification of the organism by three different laboratories, NYSDOH initiated an effort to educate clinical laboratories in New York State about the potential difficulties in characterizing the organism and the importance of primary Gram stain interpretation.
