Sentence examples for difficulty in administration from inspiring English sources

By their nature, peptide pharmaceutics are plagued with high cost of production, poor solubility, and difficulty in administration.

The use of the currently available drugs for the treatment of sleeping sickness has been limited owing to their numerous side effects, difficulty in administration and a certain loss of efficacy [ 2].

Despite exhibiting effective antibiofilm properties, the use of PDAs has been thwarted by various confounding factors such as the requirement for more contact time, difficulty in administration, and organoleptic considerations when used on food contact surfaces.

The difficulty in administration and the frequency of side effects associated with quadruple therapy treatment underline the need to search for alternative options, with a different dose of rifabutin-based triple therapy or with alternative antibiotics which should be better tolerated, easier to administer and which match or improve upon the effectiveness achieved with this reference regimen.

This type of "global" approach must be implemented in both phases of the clinical pathway: (a) in the initial phase of selection of the active substance and administration route; and (b) in the subsequent phases, characterized by the achievement of the optimal daily dosage, even in case of switching due to inefficacy, intolerance, or difficulty in administration.

After identifying unsolved practical difficulties in administration of EN using volume syringes, a new device to overcome such technical difficulties was proposed.

These treatments are beset with problems such as difficulties in administration (none are given orally), cost, duration of treatment, toxicity and resistance [3].

Despite its successful use in many different types of cancer, including conjunctival melanoma (Chalasani et al, 2006), difficulties in administration mean that MMC treatment has not been an effective treatment for primary UM.

Aside from difficulties in administration and rationale, the application of a 'fat tax' [ 108] to discourage the purchase of 'unhealthy' foods and beverages such as SSCBs, is regressive and lacks specificity, rendering this option unattractive from a health promotion perspective.

Efforts have been made to use traditional psychology assessments (eg. Bayley Scales) to monitor responses to treatment in SSPE but the degree of impairment and the fact that these measures were developed for developing infants not dementing children with physical limitations has led to difficulties in administration and scoring [ 22].

The SIRO was administered without difficulty in both administration modes.