Numerical difficulties arise from small, moving sources for the diffusion equations (see Krottje, 2003a) and from the time integration of a system that is a combination of highly nonlinear, non-stiff ODEs and stiff diffusion equations (see Verwer and Sommeijer, 2001).
Even those theatres that do play for children face great economic difficulties from the small size of audience to which puppets can play and from the modest admission fees that can be charged to children.
This, in turn.creates difficulty for small- and mid-cap companies.
"It's much easier for a chef to sit down at a computer and place an order from one or two vendors than 20 or 30," he said of the difficulties of sourcing from small farms.
Possible reasons may include the difficulty in interpreting results from small studies, statistical analysis restricted to a single marker and the use of scoring methods for assessing immunoreactivity, which often may lack validation.
Most bioassessment programs in Brazil face difficulties when scaling up from small spatial scales because larger scales usually encompass great environmental variability.
The inconsistencies seen in these trials likely reflect the difficulties in generalising results from small sample sizes, short study durations, and differences in dose of EPA (900 mg to 2010 mg) and DHA (250 mg to 960 mg).
Retailing giants that joined Amazon had difficulty differentiating themselves from smaller merchants piling onto the site.
The reason analysis of prognostic factors in SCLC has not been studied using a TMA previously is almost certainly the technical difficulty of constructing a TMA from small biopsy samples.
While the episodic disorders associated with paediatric migraine have been described over some time [14 17], the difficulties in obtaining accurate histories from small children, and a generally lessened interest in premonitory symptoms, apart from one study in a clinic population [18], have resulted in little data in the literature.
