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The major difficulty for using shadow information is due to the complicated lighting conditions in indoor environments.
However, the normalizing part Z is also a function of θ, which is the main difficulty for using the MLE method directly.
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However, it is a huge and complex database and there are some important methodological and technical difficulties for using it due to its volume and architecture.
People with multiple physical and cognitive impairments have difficulties for using properly conventional pointing devices, what reduces their possibilities to communicate and improve their cognitive and physical skills through computers.
Thus far, a comprehensive food composition database of lignans is lacking, resulting in significant difficulties for using traditional instruments to accurately quantify lignan intake.
This study highlights potential difficulties for using Q-PCR as a validation tool for transcriptome analysis in the presence of sequence polymorphism and emphasizes the need for extreme caution and thorough primer testing when assaying genetically diverse biological materials such as Pacific oysters.
9 The difficulty of using cytokines for elderly patients is well established; nevertheless, it has been reported that the efficacy still remains, even with a decreased dosage of cytokines, so bevacizumab seems to be a good drug for elderly patients.
This illustrates the difficulty of using ScvO2 for assessment of fluid therapy [ 57] because ScvO2 cannot detect preload responsiveness [ 58] or identify among volume-responders those who will benefit from fluid infusion in terms of tissue oxygenation [ 56].
However, a limitation with fitting methods is the difficulty of using a model for heterogeneous media.
Our work points out the difficulty of using standardized targets for quality-of-care indicators.
At the end of the study, participants rated the difficulty of using each device for laryngoscope imaging and passage of the tracheal tube through the glottis on a visual analog scale (VAS) from 0 mm (extremely easy) to 100 mm (extremely difficult) [ 16].
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